Effect of marjoram leaves on injured liver in experimental rats

This Study aimed to determinate some chemical composition of marjoram and investigates the treatment effect of marjoram leaves, hydro-alcoholic extract and essential oils on injured liver in experimental rats. 30 adult male Sprague Dawely rats classified into normal control (five rats) and liver injured rats groups which were nontreated group and treated groups with silymarin, marjoram leaves powder , oil and extract(each five rats).The chemical composition of marjoram leaves showed higher value of ash, protein, carbohydrate and fiber in dry weight than marjoram weight weight. Phenolic fractionations of marjoram in descending manner were protocathoic, chlorogenic, catechol, coumarone, cinnamic, caffein, vanillic, caffeic, synergic and chrisin. Marjoram leaves oils fractionations in descending manner were terpinene-4-ol, P-cymene, myrcene, γ-terpinene, β-pinene borneol, limonene, α-Pinene ,eugenol and sabinene. In compared to non treated group, the treated group with silymarin showed a significant decrease in final weight, weight gain, weight gain percent and FER and also serum ALT &AST, ALP, creatinine and total bilirubin , MDA ,liver cholesterol and total lipids but a significant increase in serum globulin ,serum CAT, liver TAC and in both serum and liver SOD . The treated group with marjoram leaves showed a significant decrease in gain percent and serum ALT &AST, creatinine, uric acid .total bilirubin , MDA, liver triglycerides, liver cholesterol and liver total lipids but a significant increase in serum globulin , serum CAT , liver TAC and liver SOD. The treated group with marjoram oil showed a significant decrease in final weight, weight gain, weight gain percent and FER and also serum ALT, ALP, creatinine, uric acid, total bilirubin ALP, MDA and liver triglycerides but a significant increase in globulin, liver cholesterol while treated group with marjoram extract showed a significant decrease in final weight, weight gain, weight gain percent and FER and also serum ALT, ALP, creatinine ,uric acid , total bilirubin ,liver triglycerides but a significant inecrease in globulin ,liver cholesterol.The treated groups with silymarin, marjoram leaves, oil and extract showed a significant decrease in serum cholesterol, triglycerides, LDL-c , VLDL-c and CHO/HDLc and a significant increase in serum HDL-c but a significant increase in serum TAC and liver CAT but a significant decrease in liver MDA. [Abd El-Ghany, M. A & Nanees , Y. El-Metwally. Effect of marjoram leaves on injured liver in experimental rats. Report and Opinion 2010;2(12):181-191]. (ISSN: 1553-9873). http://www.sciencepub.net.